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Prednisolone for Dogs, Cats, and Horses

By Evan Ware, DVM

Commonly prescribed for: Inflammation, immunosuppression, pruritis, recurrent airway obstruction in horses

Species: Dogs, Cats, and Horses

Therapeutic Class: Glucocorticoid


Basic Information

Prednisolone Acetate is an adrenocortical steroid that is used to reduce inflammation in dogs, cats, horses, and cattle. It is administered in the form of eye drops but also is available as an injectable solution. Its efficacy is well known, and it is widely prescribed by veterinarians.

Veterinary Medicine Uses for Prednisolone Acetate

Prednisolone binds with glucocorticoid receptors and influences cell behavior by acting as a catalyst to produce some proteins, and as an inhibitor to synthesize others, suppressing inflammation and immune response in the process.

In veterinary medicine, Prednisolone Acetate is prescribed to treat pain and inflammation resulting from surgery, injuries, and infections.

Potential Side-Effects of Prednisolone Acetate

If pregnant animals ingest Prednisolone Acetate, premature birth or birth defects can result, so caution is urged when giving Prednisolone Acetate to nursing animals.

Pet owners should be alert for itching, facial swelling, respiratory distress, or other bothersome side effects.

Precautions for Using Prednisolone Acetate

Prednisolone Acetate ophthalmic solution should not be administered to animals who are allergic to any of the ingredients it contains. Alternate formulations free of potential allergens may be available from pharmacies specializing in pharmaceutical compounding.

It important not to begin treatment with Prednisolone Acetate in animals who have ulcers of the eye, as it can cause this condition to worsen. Prednisolone Acetate can result in fungal or bacterial infections if used for extended periods of time.

Do not suddenly discontinue this medication for animals who have been treated with it for several weeks, as doing so can cause very serious adverse effects.

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