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By Barbara Forney, VMD
Last reviewed: 7/13/2022
Commonly prescribed for: Spinal-cord injury (SCI), Traumatic Brain Injury
Therapeutic Class: Hydrophilic Polymer
Polyethylene glycol (PEG) is a hydrophilic polymer that has been used in experimental studies as a reparative agent to treat SCI and, more recently, traumatic brain injury in laboratory animals. It soon may be used in human clinical trials. At this time, the majority of the research on the use of PEG in animals has been conducted at the Center for Paralysis Research at Purdue University. Additional Information: A Preliminary Study of Intravenous Surfactants in Paraplegic Dogs: Polymer Therapy in Canine Clinical SCI. Journal of Neurotrauma Volume 21, Number 12, 2004.(1) PEG is a water-soluble polymer that has been shown to repair or seal the cellular plasma membrane of damaged axons. PEG also enters injured cells and protects mitochondrial function and reduces the release of cytochrome-c, a cellular-death factor. The repair of nerve membranes by polymeric sealing can lead to rapid and dramatic improvement in function. PEG preferentially targets injured tissue within the central nervous system. It has been studied using direct application to the site of trauma, intravenous therapy, and intraperitoneal and subcutaneous administration. In experimental studies, systemically administered fluorescein labeled PEG marked the site of the damaged spinal cord, as well as local direct application. Much of the experimental work that is now being conducted uses subcutaneous PEG.
We can let your veterinarian know that you are interested in our compounded Polyethylene Glycol.
Flavored, medicated oral soft chew treats.
Flavored oral dry dosage form, ideal for mixing in food.
Oral medication available in gelatin or veggie capsule options.
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