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By Barbara Forney, VMD
Commonly prescribed for: Pituitary-dependent Hyper-adrenocorticism (PDH)
Therapeutic Class: Adrenal-cytotoxic
Mitotane is an adrenal cytotoxic drug that is derived from the insecticide DDT. It commonly is used to treat PDH in dogs. Mitotane causes severe, progressive, cellular necrosis of the zona fasciculata and the zona reticularis. To a much lesser degree it also may affect the zona glomerulosa. Mitotane also may inhibit adrenocortical function without causing cell death, although in this case the mechanism of action is not known. Mitotane is stored in body fat, metabolized by the liver, and excreted in both bile and urine.
We can let your veterinarian know that you are interested in our compounded Mitotane.
Dosage options starting at $0.84 per dose
Oral medication available in gelatin or veggie capsule options.
Oil based oral suspension with a wide variety of flavoring options.
Water based oral suspension with a wide variety of flavoring options.
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This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.