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By Barbara Forney, VMD
Last reviewed: 7/13/2022
Commonly prescribed for: Ventricular arrhythmias
Therapeutic Class: Oral antiarrhythmic
Mexiletine is a Class 1B, sodium channel blocker, anti-arrhythmia drug that is used to treat chronic ventricular arrhythmias in the dog. The mechanism of action is similar to lidocaine. Mexiletine is used to treat ventricular arrhythmias including PVC’s and ventricular tachycardia. If an animal has responded well to lidocaine during an acute episode, it is likely to respond well to mexiletine. Mexiletine is well-absorbed orally and has a bioavailability of approximately 85%. It is primarily excreted in the urine although approximately 10% is metabolized by the liver and excreted in the feces. The half-life of this drug may be prolonged in animals with reduced cardiac output, or after an acute myocardial infarction. The half-life may also be prolonged in animals with hepatic dysfunction or severe kidney disease.
We can let your veterinarian know that you are interested in our compounded Mexiletine.
Dosage options starting at $0.50 per dose
Flavored chewable oral tablets.
Oral medication available in gelatin or veggie capsule options.
Water based oral suspension with a wide variety of flavoring options.
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This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.