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By Barbara Forney, VMD
Last reviewed: 9/20/2022
Commonly prescribed for: Immunosuppressants
Therapeutic Class: Purine-antagonist Anti-metabolite
Azathioprine is a purine-antagonist anti-metabolite that primarily is used as an immunosuppressant in dogs. It competes with purine in the synthesis of nucleic acids. It also inhibits the synthesis of T-lymphocyte-dependent antibodies and cyclo-oxygenase. Azathioprine is absorbed from the GI tract and metabolized to mercaptopurine. The incidence of bone-marrow suppression is thought to be related to levels of one of the important enzymes involved in the metabolism of azathioprine-thiopurine methyltransferase (TMPT). Cats have low TMPT activity and are prone to azathioprine toxicity. Humans with low TMPT-levels are more likely to experience bone marrow suppression. There is conflicting research regarding TMPT activity in dogs and the incidence of myelotoxicity. Metabolites of azathioprine and mercaptopurine are excreted by the kidneys.
We can let your veterinarian know that you are interested in our compounded Azathioprine.
Dosage options starting at $0.81 per dose
Oral medication available in gelatin or veggie capsule options.
Water based oral suspension with a wide variety of flavoring options.
Oil based oral suspension with a wide variety of flavoring options.
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