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Tripelennamine is an antihistamine. It competitively inhibits histamine binding at the H1 receptors on sensitive cells in the respiratory tract, intestines, blood vessels, and skin. When compared to other antihistamines, tripelennamine has minimal anticholinergic properties and is only moderately sedating.
Tripelennamine is used in horses to treat allergic problems such as hives and itchy skin reactions or more urgent allergic problems such as tongue or facial swelling due to bee sting, insect bites, or contact with an irritating plant. Oral antihistamines generally take 20 - 45 minutes to exert an effect, whereas injectable antihistamines such as tripelennamine or pyrilamine maleate act more rapidly. Injectable antihistamines, however, are more likely to cause adverse side-effects.
If antihistamines alone are unable to control all of the allergic signs, they may be used with corticosteroids allowing use of a lower dose of the corticosteroids.
Overdoses can cause either increased sedation and ataxia, or CNS excitement and seizures.
May Be Prescribed by Vets for:
Hives, bee stings, itchy skin and allergic skin conditions
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Barbara Forney, VMD
Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
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This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.
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