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Tolfenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and cyclooxygenase inhibitor. It is used for the management of both acute and chronic pain in dogs and acute pain for cats. The pharmacologic effects of tolfenamic acid are similar to those of aspirin. It inhibits prostaglandin release and has a direct inhibitory effect on prostaglandin receptors. It also decreases platelet aggregation. Tolfenamic acid is well-absorbed after oral administration. It is generally used as a once a day drug with peak levels occurring at two to four hours after administration.
There is active research in humans and dogs regarding the use of tolfenamic acid as an anti-cancer drug. Wilson et al. (J Vet Intern Med 2012) reported on the use of tolfenamic acid in vitro on canine osteosarcoma, mammary carcinoma, and melanoma cell lines. Tolfenamic acid is an approved veterinary drug in Canada and Europe but it is not approved in the United States.
Dog and Cats
Tolfenamic acid may be used by injection intramuscular or subcutaneous or orally. Protocols for using tolfenamic acid in both dogs and cats recommend only administering the drug for two to five days followed by a similar number of day without medication. This cycle may be repeated.
Non-steroidal anti-inflammatory (NSAID)
Dogs and Cats
May Be Prescribed by Vets for:
Pain relief, anti-inflammatory, antipyretic
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Barbara Forney, VMD
Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
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This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.