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Tacrolimus is one of a group of relatively new drugs called Calcineurin inhibitors. These drugs are anti-inflammatory, and immunosuppressive or immunomodulatory. The mechanism of action is through the inhibition of calcium-dependent pathways that effect the enzymatic action of Calcineurin. This, in turn, blocks the proliferation of T-lymphocytes and cytotoxic cells. When one reviews the human literature, Calcineurin inhibitors are investigated widely for use in atopic dermatitis and in organ transplant recipients. At the present time, veterinary use of tacrolimus is primarily for keratoconjuctivitis sicca in dogs and cats and immune-mediated dermatologic diseases.
We can let your veterinarian know that you are interested in our compounded Tacrolimus.
Keratoconjunctivitis sicca due to decreased tear production is primarily an immune-mediated disease of the lacrimal glands. It is seen more commonly in dogs than in cats. Cyclosporine and tacrolimus are the two drugs most commonly used to stimulate tear production. Cyclosporine has been the standard drug for years although topical ophthalmic tacrolimus is thought to be considerably more effective; as a result it may be useful in animals that are refractory to cyclosporine. Animals with immune-mediated KCS will need to be on treatment for the rest of their lives.
Topical tacrolimus also may be useful in localized treatment of atopic dermatitis, pemphigus, lupus erythematosus complex, miliary dermatitis, and eosinophilic granuloma complex.
Only topical use of tacrolimus is recommended currently. There is not sufficient information regarding systemic use.
No information regarding drug interactions was found in the literature.
Dogs and cats
May Be Prescribed by Vets for:
Keratoconjunctivitis Sicca, Atopic dermatitis.
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Barbara Forney, VMD
Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
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This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.