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Spironolactone is an aldosterone antagonist that is used as a potassium-sparing diuretic. It is most commonly used in animals in congestive heart failure or for those with ascites. Spironolactone is an older drug but recent research still supports its use. This drug is approved for use in human medicine and is marketed under the brand name of Aldactone™ .
Spironolactone competitively inhibits aldosterone at the mineralocorticoid receptor of target cells in the distal renal tubules. It increases the excretion of sodium, chloride, and water, while sparing potassium, ammonium, and phosphate. It appears to have its greatest effect in animals with elevated aldosterone and to have less effect in animals with normal aldosterone levels. Spironolactone has been shown to have some additional cardioprotective effects in humans with elevated aldosterone. It may also act as a vasodilator through a mechanism similar to calcium channel blockers.
Spironolactone can be thought of as a prodrug as it is rapidly metabolized in the liver to canrenone and other active metabolites. It is primarily eliminated via the kidney. In humans, oral absorption is improved by administration with food. Spironolactone is not thought of as an emergency drug as peak diuresis may not occur until two to three days of therapy.
Spironolactone is used to help manage refractory edema or fluid retention due to congestive heart failure, cirrhosis of the liver, ascites, hypertension, feline primary hyperaldosteronism, and nephrotic syndrome. It is used with furosemide, digoxin, and ACE 1 inhibitors in dogs with chronic congestive heart failure. The addition of spironolactone may allow a lower dose of furosemide. Research in both humans and in dogs would indicate improved survival when spironolactone is added to the conventional congestive heart failure treatment.
There is little information available on overdose in animals. If an oral overdose is recognized promptly, gut-emptying protocol may be of benefit. Monitoring and support of hydration status and electrolyte status should be performed.
Dogs and Cats
May Be Prescribed by Vets for:
Congestive heart failure
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Barbara Forney, VMD
Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
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This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.
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