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Pharmacokinetics of oral gabapentin in Greyhound dogs

Vet J. Author manuscript; available in PMC 2012 January 1.

Published in final edited form as: Vet J. 2011 January; 187(1): 133–135.

Published online 2009 October 23. doi:  10.1016/j.tvjl.2009.09.022  

PMCID: PMC2891228 NIHMSID: NIHMS150465

Butch KuKanich and Rachael L Cohen Author information  Copyright and License information  The publisher's final edited version of this article is available at Vet J

Abstract

Keywords: Analgesic, Anticonvulsant, Veterinary, Dog, Pharmacology

The purpose of this study was to assess the pharmacokinetics of gabapentin in healthy Greyhound dogs after single oral doses targeted at 10 and 20 mg/kg PO. Six healthy Greyhounds were enrolled (3 males, 3 females). Blood was obtained at predetermined times for the measurement of gabapentin plasma concentrations by liquid chromatography/mass spectrometry. Pharmacokinetic parameters were determined with computer software. The actual mean (and range) doses administered were 10.2 (9.1–12.0) mg/kg and 20.5 (18.2 – 24) mg/kg for the 10 mg/kg and 20 mg/kg targeted dose groups. The mean CMAX for the 10 and 20 mg/kg groups were 8.54 and 13.22 μg/mL at 1.3 and 1.5 h, and the terminal half-lives were 3.3 and 3.4 h, respectively. The relative bioavailability of the 10 mg/kg group was 1.13 compared to the 20 mg/kg group. Gabapentin was rapidly absorbed and eliminated in dogs indicating frequent dosing is needed to maintain minimum targeted plasma concentrations.  

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