Ordering compounded medications is easier than ever. Log in with your secure digital account and gain instant access to the industry’s largest formulary of compounded medications – 24 hours a day, 7 days a week.
Ordering your pet's prescription drugs from Wedgewood Pharmacy is safe, and convenient. With a prescription number, easily refill prescriptions and enroll in the AutoRefill Program.
May Be Prescribed by Vets for:
Search for Available Dosage Forms
Mirtazapine is a tetracyclic anti-depressant that is prescribed by veterinarians to treat a wide range of conditions, from behavioral problems to loss of appetite in cats. Mirtazapine is particularly useful for patients with anxiety and sleep disturbance. It has a rapid onset of action in comparison to many anti-depressant medications. It has a dual mechanism of action, being both a noradrenergic and specific serotonergic drug (NaSSA). Mirtazapine is metabolized primarily by the liver.
Mirtazapine is used as an appetite stimulant for dogs and cats that are refusing to eat. It also is prescribed for long-term treatment of various patients who are experiencing nausea, vomiting, and anorexia.
There is very little scientific information available on this drug in cats, although it is mentioned in the proceedings of a number of feline veterinary meetings. Anecdotal reports of use include cats with chronic renal failure, pancreatitis, diabetes mellitus, and other depressed, older, sick-cat situations. Possible advantages for using mirtazapine over cyproheptadine are once every three days dosing and the anti-emetic properties. In human medicine, the notable downside to mirtazapine is weight gain. When treating sick, anorectic cats, this might be considered a positive attribute.
Other uses for mirtazapine include treating behavioral problems like separation anxiety, urine spraying, and insomnia.
Mirtazapine generally is well tolerated in dogs and cats, although trials are lacking. Common side- effects include drowsiness, sedation, low blood pressure, and increased heart rate.
If the animal experiences breathing difficulties, hives or swelling of the lips, tongue, or face, then an allergic reaction to the drug can be the case.
The most-common side effects in humans are somnolence, dry mouth, increased appetite, and weight gain.
Based on human literature, mirtazapine has fewer drug-interactions than many of the other drugs used to treat depression. There is no specific information available about treatment in cats.
Mirtazapine has a wide margin of safety in humans. No information was found in the literature regarding cats. If an overdose is recognized promptly, gut-emptying protocols can be tried.
Mirtazapine should not be prescribed or administered to a patient that is hypersensitive or allergic to the medication. It also should be used with caution whenever the animal is taking other medications, as it can interact with other drugs, including Tramadol and monoamine oxidase inhibitors.
Mirtazapine is available from compounding pharmacies in varying strengths of oral and topical formulations. The dosage, formulation, and frequency of administration are determined according to what the drug is being used to treat and the type and size of animal receiving the treatment.
Since this medication is an anti-depressant, abrupt cessation of the drug is not recommended. The animal should be weaned off mirtazapine over an acceptable period of time.
Dr. Evan Ware is a veterinary practitioner in Phoenix, Arizona. He received both his undergraduate degree in microbiology and his Doctorate of Veterinary Medicine from The Ohio State University.
Dr. Ware is currently the Medical Director of University Animal Hospital (VCA) and is also the owner of two other hospitals, including Laveen Veterinary Center and Phoenix Veterinary Center. His areas of interest include orthopedic medicine and surgery, veterinary oncology and chemotherapy, and general and advanced soft-tissue surgery.
Some states restrict the information we may provide about controlled substances. Please select your state below.
405 HERON DRIVE SUITE 200 • SWEDESBORO, NJ 08085-1749 | © 2004-2021 WEDGEWOOD PHARMACY, ALL RIGHTS RESERVED.
This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.
As part of our transition to Wedgewood Pharmacy, DiamondbackDrugs.com is no longer active. You have been redirected to the Wedgewood Pharmacy site.
We look forward to serving you in the future as part of the largest animal-health compounding pharmacy in the U.S.