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Melarsomine is an antiparasitic medication derived from an organic arsenic compound that is used in a veterinary hospital setting to treat dogs that are suffering from heartworm disease.
Melarsomine contains arsenic, which is the active ingredient that kills both the adult and immature (>4 months old) heartworms. After treatment with melarsomine, the patient should undergo cage rest for four to six weeks. Additional medications that is used to treat heartworm disease include other antiparasitics, antibiotics, and steroids.
The most-common side effects of melarsomine include pain, swelling, and tenderness at the injection site; fever, lethargy, a loss of appetite, vomiting, gagging, lung congestion, and depression. Hard nodules also can develop and persist at the injection site. Older dogs, such as those aged eight years or older, tend to be more susceptible to depression, vomiting, and loss of appetite as compared to younger patients.
More-severe side effects of melarsomine, although rare, include coughing up blood, diarrhea, excessive drooling and panting, and death. It is important to note that these signs can be directly related to treating heartworm disease and not necessarily the drug itself.
For this reason, surgical removal of the heartworm may be recommended to help improve the patient's prognosis. If left untreated heartworm disease can prove fatal, so the risks of treatment are usually accepted.
Although melarsomine is FDA-approved for use in canines, there are certain situations where the drug should be avoided or used with extreme caution. For instance, if the pet has a known allergy to melarsomine, it should be avoided. This medication also should be used with extreme caution in patients who are pregnant, nursing, or already receiving treatments for other diseases, especially those affecting the kidneys or lungs.
Melarsomine is approved for use in dogs only. It never should be administered to cats or to other pets.
Melarsomine has been shown to interact with Caparsolate and glucocorticoids, so extra care needs to be practiced in these types of cases.
When it is in its powder form, melarsomine should be stored upright at room temperature. Once reconstituted, however, the medicine should be stored in a refrigerator. Melarsomine should be disposed of if not used within 24 hours after reconstitution.
May Be Prescribed by Vets for:
Treatment of heartworm
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Evan Ware, DVM
Dr. Evan Ware is a veterinary practitioner in Phoenix, Arizona. He received both his undergraduate degree in microbiology and his Doctorate of Veterinary Medicine from The Ohio State University.
Dr. Ware is currently the Medical Director of University Animal Hospital (VCA) and is also the owner of two other hospitals, including Laveen Veterinary Center and Phoenix Veterinary Center. His areas of interest include orthopedic medicine and surgery, veterinary oncology and chemotherapy, and general and advanced soft-tissue surgery.
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This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.