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Lincomycin is a lincosamide antibiotic. The other antibiotic in this group is clindamycin. These antibiotics are primarily used in companion animals to treat gram-positive bacterial infections. The mechanism of action is through the inhibition of protein synthesis within the bacterial cell. Lincosamide antibiotics can be either bacteriostatic or bactericidal, depending on the antibiotic concentration and the susceptibility of the organism.
Lincomycin is available in oral, intramuscular, and intravenous forms. It is rapidly but incompletely (30 - 40%) absorbed following oral administration. Food may decrease the rate and amount of absorption. There have been recent pharmacokinetic studies that indicate that once a day dosing for clindamycin is superior to the customary twice a day dosing. Lincomycin is well distributed through most tissues with the exception of the central nervous system. It is metabolized by the liver and excreted in urine, feces, and bile. Lincomycin levels may accumulate in animals with decreased liver or kidney function.
Lincomycin is an older antibiotic from the same family as clindamycin. Clindamycin has a slightly broader spectrum of activity, but both are used to treat susceptible gram-positive and anaerobic-bacterial infections. Lincomycin is commonly used for superficial and deep skin infections.
It is particularly useful to treat infections in animals that are allergic to penicillins and cephalosporins.
There is a wide margin of safety for oral overdose. If recognized promptly, gut-emptying protocols may be of some benefit.
Dogs and Cats
May Be Prescribed by Vets for:
Susceptible bacterial infection
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Barbara Forney, VMD
Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
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This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.
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