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Isoxsuprine is a mixed beta-adrenoreceptor antagonist/agonist. It causes relaxation of vascular and uterine smooth muscle. In addition to peripheral vasodilation, isoxsuprine has been shown to decrease blood viscosity and platelet adherence. Isoxsuprine is primarily used in veterinary medicine to treat or manage navicular disease in the horse. It is used in human medicine as a tocolytic agent to decrease preterm labor or abortion. The human gastrointestinal tract absorbs isoxsuprine well, but studies in the horse indicate that oral bioavailability is approximately 2.2%.
Isoxsuprine is used in horses for the management of navicular disease and laminitis. Due to the low bioavailability in the horse, treatment with oral isoxsuprine is not universally accepted, but there are veterinarians who feel it is beneficial in some cases.
Because of its demonstrated tocolytic properties in humans, some veterinarians have used isoxsuprine for the same purpose in broodmares. Its efficacy for this use has not been well-evaluated.
Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
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This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.