Ordering compounded medications is easier than ever. Log in with your secure digital account and gain instant access to the industry’s largest formulary of compounded medications – 24 hours a day, 7 days a week.
Ordering your pet's prescription drugs from Wedgewood Pharmacy is safe, and convenient. With a prescription number, easily refill prescriptions and enroll in the AutoRefill Program.
Gabapentin, an analog of gamma-aminobutyric acid, exhibits anticonvulsant
properties in both animal models and humans. Gabapentin pharmacokinetics was
studied in laboratory animals using HPLC and radiometry. Oral bioavailability
was 40% in monkeys administered 25 mg/kg, 79% in mice and rats receiving 50
mg/kg, and 80% in dogs administered 50 mg/kg. Binding to plasma proteins was <
3%. Maximum blood or plasma concentrations generally occurred within 2 hr of an
oral dose. In rats and monkeys, increases in maximum plasma concentrations
and/or areas under the curve were less than dose-proportional following oral
administration, most likely because of saturable absorption. However,
intravenous pharmacokinetics in rats were linear over the dosage range of 4-500
mg/kg. Mean intravenous elimination half-life was 1.7 hr in rats, 2.9 hr (14C
only) in dogs, and 3.0 hr in monkeys. In rats and dogs, repeated administration
did not alter gabapentin or 14C pharmacokinetics. Additionally, gabapentin did
not induce hepatic cytochrome P450 monooxygenases in rats. There were no age-
(rats only) or gender-associated changes in pharmacokinetic parameters.
[14C]Gabapentin was extensively distributed to tissues. In the dog, gabapentin
was metabolized to N-methylgabapentin (approximately 34% of dose); whereas
metabolism in mouse, rat, and monkey was minimal (< 5%). The principal route of
excretion was via urine. In summary, as an antiepileptic drug, gabapentin
exhibited desirable pharmacokinetic properties, such as linear elimination
kinetics, not highly bound to plasma proteins, not extensively metabolized, and
not an inducer of hepatic cytochrome P450.
PMID: 7600909 [PubMed - indexed for MEDLINE]
For more information.
Some states restrict the information we may provide about controlled substances. Please select your state below.
405 HERON DRIVE SUITE 200 • SWEDESBORO, NJ 08085-1749 | © 2004-2021 WEDGEWOOD PHARMACY, ALL RIGHTS RESERVED.
This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.