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Dipyrone (metamizole) is a nonsteroidal anti-inflammatory drug. The mechanism of action of dipyrone is thought to be similar to that of other NSAIDs: inhibition of the production of prostaglandins. It commonly is used in the horse as an antipyretic, analgesic and anti-inflammatory.
Dipyrone is a very mild NSAID. Because of its very mild analgesic properties it is unlikely to mask abdominal pain due to a surgical problem. Traditionally, dipyrone has been thought also to have anti-spasmodic properties on the smooth muscle of the gastrointestinal tract, which has been the basis for its common use in cases of mild colic. Although research evidence does not support any claim of anti-spasmodic activity, many clinicians consider it a very useful drug precisely for this reason. Flunixin meglumine is an NSAID with stronger analgesic properties that also is used to treat GI pain.
Dipyrone may be used in foals and in adult horses to reduce fevers. It is not used commonly to treat musculoskeletal pain. Dipyrone may be given IM, IV or subcutaneously.
Convulsions have been reported following acute overdose.
Nonsteroidal anti-inflammatory drug
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Barbara Forney, VMD
Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
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This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.
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