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Dogs and cats
May Be Prescribed by Vets for:
Allergies, antiemetic and sedative.
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Diphenhydramine is an antihistamine that competitively inhibits histamine binding at the H1 receptors. Antihistamines do not block the release of histamine but compete for uptake at the receptors on sensitive cells in the respiratory tract, intestines, blood vessels and skin.
Diphenhydramine is used in companion-animal practice to treat allergies and atopy primarily in dogs. Antihistamines alone can control pruritis in 20-40% of atopic dogs. If antihistamines are unable to control all of the allergic signs, they may be used with corticosteroids, allowing use of a lower dose of the corticosteroids. The sedative effects seen with diphenhydramine use also may help with agitation associated with allergic symptoms. Antihistamines should not be used within a week of skin testing for allergies.
Diphenhydramine also may be used as an antiemetic and frequently is used to prevent motion sickness in dogs. H1 histaminergic receptors play a role in the emetic response associated with motion sickness in dogs (but not in cats). Diphenhydramine will cause some central nervous system (CNS) depression and sedation, although the sedative effects may diminish with time. When using oral diphenhydramine for motion sickness, it should be given 30 to 60 minutes before traveling.
H1 blockers such as diphenhydramine and H2 blockers such as ranitidine or cimetidine are used in dogs prior to surgical excision of mast cell tumors in order to prevent some of the effects of massive histamine release due to mast cell de-granulation. These drugs generally are continued during the recovery period in order to improve wound healing. Diphenhydramine also is used to treat neurotoxicity or extrapyramidal effects due to phenothiazines, metoclopramide, and tremors due to organophosphate or carbamate poisoning.
Chlorpheniramine is the antihistamine of choice for pruritis, alopecia and motion sickness in cats.
Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
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This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.