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Synthetic Estrogen (nonsteroidal)
Dogs and cats
May Be Prescribed by Vets for:
Urinary incontinence, mismating, prostatic hypertrophy, treatment of estrogen-responsive neoplasia, and induction of heat.
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Diethylstilbestrol (DES) is a synthetic estrogen. Estrogen is one of the primary ovarian hormones and the pharmacologic actions of DES mimic those of estrogen. These include development and maintenance of female sexual organs and secondary sex-characteristics. Estrogens affect the release of pituitary hormones, affecting lactation, ovulation androgen, and other hormone secretion. They have some mild anabolic effects and have multiple effects on the skeletal system including increasing calcium deposition, bone formation, and accelerating epiphyseal-closure. Estrogen also can increase sodium and water retention. DES is well-absorbed from the gastrointestinal tract.
DES is used primarily to treat urinary incontinence in spayed females. Estrogens increase urethral tone and help to prevent leaking or dribbling of urine. DES usually is effective for this purpose and the risk of side effects is relatively low due to the small dose. DES may be used with the alpha-agonist phenylpropanolamine. These drugs behave in a synergistic fashion.
DES has been used to prevent pregnancy due to accidental breeding or mismating in dogs and cats. It generally is not recommended for this purpose, as it is not very effective. DES is used in the management or treatment of prostatic hypertrophy. The definitive and preferred treatment for prostatic hypertrophy is castration but in cases where that is not an option, a short course of DES has been shown to reduce prostatic secretion markedly for up to two months. The risk of adverse effects increases with multiple treatments. DES also is used to treat certain hormonally responsive tumors including perianal gland adenoma, although this use is controversial due to side effects. DES also has been used experimentally in combination with other hormones for inducing estrus. Different protocols combine DES with LH, FSH and HCG. This work is still experimental and not widely used clinically.
Overdose in humans resulted in nausea, vomiting and bleeding.
Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
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