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Clopidogrel is a thienopyridine class, antiplatelet drug. The human trade name is Plavix. It is commonly used in human medicine for stroke patients and those at risk for myocardial infarction due to thrombus formation. Ticlopidine is also a thienopyridine drug, but is less commonly used in veterinary medicine due to a higher incidence of adverse effects when compared to clopidogrel.
Clopidogrel is a pro-drug and must undergo hepatic metabolism to its active metabolite. The mechanism of action is through the irreversible inhibition of the adenosine diphosphate receptor on platelet cell membranes. There is some variability in the literature regarding time to achieve steady state levels (3-7 days). Clopidogrel has a different mechanism of action than aspirin and is frequently combined with aspirin in both human and veterinary patients.
Clopidogrel is an oral antiplatelet-drug that is used in cats with cardiomyopathy, and in dogs with underlying hypercoagulability. Studies in the cat have shown it to have significant anti-platelet drug activity at a wide range of dosages. It is particularly useful in animals that are unable to tolerate aspirin. Although treatment of pre-clinical hypertrophic cardiomyopathy (HCM) remains controversial, there are many clinicians who use clopidogrel and other cardiac drugs in the asymptomatic cat with HCM.
Clopidogrel is used in dogs for the treatment of immune-mediated hemolytic anemia. Although there are multiple reports regarding its use in the dog, there is not as much clinical experience in the dog as in the cat.
Clopidogrel is generally well tolerated in the cat. The most commonly-reported side effects are nausea and anorexia. These side effects may be lessened by administration with food.
Extrapolating from the precautions in human medicine would indicate that clopidogrel should not be used in animals with active bleeding. There is no specific precautionary information available for cats and dogs.
Dogs and Cats
May Be Prescribed by Vets for:
Cats: Arterial thromboembolism
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Barbara Forney, VMD
Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
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This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.
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