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Dogs and cats
May Be Prescribed by Veterinarians for:
Susceptible bacterial infections and some protozoal infections: Toxoplasma
Approved for use in dogs and cats. Clindamycin is commercially available as capsules/tablets (Antirobe/ClinCaps/ClinTabs): 25mg/75mg/150mg/300mg. Oral Solution (Antirobe/ClindaCure/Clinda-Guard/ClindaMed/ClinDrops/ClinSol/ZydaClin): 25mg/ml. Injection 150mg/ml. IV 150mg/ml.
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Clindamycin is a broad-spectrum lincosamide antibiotic. It is efficacious against gram-positive aerobic bacteria (including most Staphylococcus and Streptococci spp), anaerobic bacteria, and some protozoal infections (including Toxoplasma). Clindamycin is approved by the FDA for use in dogs and cats with the following label indications: wounds, abscesses, and osteomyelitis (Staph aureus).
Clindamycin may be either bacteriostatic, or bactericidal depending on drug concentration at the site of infection. It is well distributed and penetrates bone, joints, pleura, peritoneal fluid, the heart, and abscesses. Clindamycin crosses the blood brain barrier and is present in the CNS at about 40% serum levels if there is concurrent meningeal inflammation. Clindamycin is well absorbed orally and is partially metabolized in the liver. It is excreted in urine, feces, and bile.
Clindamycin is used to treat a variety of infections in dogs and cats. Its indications in dogs include Staph pyoderma, wounds, abscesses, dental infections, osteomyelitis, susceptible hepatobiliary or respiratory infections, anaerobic infections, intra-abdominal sepsis, actinomycosis, some methicillin resistant Staph infections, and susceptible protozoal infections, including Toxoplasmosis. It is used for very similar indications in the cat.
Clindamycin is considered the treatment of choice for clinical Toxoplasmosis in both dogs and cats. The dose used for the treatment of Toxoplasmosis is generally higher than that for susceptible bacterial infections. Some improvement of clinical signs usually occurs within the first 48 hours of treatment, although neurologic deficits, muscle atrophy, and ocular lesions may take longer to resolve.
When clindamycin is used to treat mixed bacterial infections, it may be combined with aminoglycosides, 3rd generation cephalosporins, or flouroquinolones to provide adequate gram negative coverage.
Food may affect the rate but not the extent of absorption.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
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