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Chloramphenicol/Prednisolone/ Tetracaine/Squalane

by Barbara Forney, VMD

Basic Information

Wedgewood Pharmacy compounds Chloramphenicol/Prednisolone/ Tetracaine/Squalane 4.2mg/1.7mg/4.5mg/0.21ml/ml Ointment in response to the discontinuation of Liquachlor by the manufacturer. Changes in the regulatory environment have caused many commercial combination products to no longer be manufactured by drug companies. They must now be compounded by a compounding pharmacy.

The squalane is useful for softening and dissolving wax and debris in the external ear canal. Chloramphenicol/Prednisolone/Tetracaine/Squalane 4.2mg/1.7mg/4.5mg/0.21ml/ml Ointment does not have an antifungal component.


Chloramphenicol/Prednisolone/Tetracaine/Squalane 4.2mg/1.7mg/4.5mg/0.21ml/ml Ointment is used in the treatment of bacterial or allergic otitis. Frequently otitis externa has both a bacterial and an inflammatory component and many treatment regimens are based on combination therapy.

Side Effects

Some animals are sensitive to topical anesthetics. In cases that fail to respond, the medication itself may be contributing to the problem.


  • This preparation should not be used in animals in which the tympanic membrane is ruptured.
  • This preparation should be used only if there is a bacterial component to the otitis externa.

Drug Interactions

Corticosteroids applied to the external ear canal are absorbed systemically. The effects may be additive with other systemic corticosteroids.


Overdose of topical medication is not likely to cause a problem except with the corticosteroid as noted in the drug interactions.

For Veterinary Practices
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For Pet & Horse Owners
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Therapeutic Class
Combination antibiotic, corticosteroid, local anesthetic, ceruminolytic


May Be Prescribed by Vets for:
Bacterial, allergic otitis.

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About the Author

Dr. Barbara Forney

Barbara Forney, VMD

Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.

She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.

Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.