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General Drug Information and IndicationsHow to Give this MedicationSide EffectsPrecautionsDrug InteractionsOverdoseStorageSearch for Available Dosage Forms
Cisapride is a drug that is used to stimulate the smooth muscle that lines the digestive tract, causing the contents to move further along through the esophagus, stomach and the intestines. Cisapride is used in cats for conditions such as megaesophagus, chronic constipation and megacolon. It is used in dogs to reduce vomiting associated with megaesophagus, or other conditions that slow the emptying of the stomach. Like many other drugs in veterinary medicine, Cisapride is not FDA approved for use in animals; however, it may be compounded by a specialty pharmacy for your pet. Cisapride is considered accepted practice within veterinary medicine.
Give this medication to your pet exactly as your veterinarian prescribes. If you miss giving your pet a dose of cisapride, give the next dose as soon as you remember or, if it is close to the next scheduled dose, return to the regular schedule. Do not double dose in order to catch up.
Cisapride is usually given at least 30 minutes before feeding.
Cisapride does not cure the condition for which it is given. Treatment is generally continued for the life of the animal.
Wash your hands after giving your pet this medication.
Be sure to discuss any side effects with your veterinarian immediately.
Cisapride is generally well tolerated in cats and dogs. The most common side effects are vomiting, diarrhea or abdominal pain.
Keep this and all drugs out of reach of children. Cisapride is a prescription drug and should be used according to your veterinarian’s directions. It should only be given to the animal for which it was prescribed. Do not give this medication to a person.
If your pet has severe liver disease, the vet may lower the cisapride dose.
High doses of cisapride have been shown to cause problems during pregnancy in laboratory animals and appears in maternal milk in small amounts. Cisapride would only be used during pregnancy or in nursing animals when the benefits outweigh the risks.
Be sure to review with your veterinarian any drugs your pet may be taking.
Cisapride is metabolized by the liver. If taken with other drugs that are also metabolized the same way in the liver, they may interfere with cisapride levels. These drugs include: Amiodarone, ketoconazole, itraconazole, fluconazole, chloramphenicol, cimetidine, fluvoxamine, grapefruit juice or powder, and certain antibiotics such as erythromycin.
Although changes in heart rhythm due to cisapride are rare, there are some other drugs that also can change the heart rhythm. If cisapride is used with these drugs, the risk for heart complications increases. These drugs include amiodarone, clarithromycin, moxifloxacin, procainamide, quinidine, sotalol and tricyclic antidepressants.
Because cisapride decreases the amount of time it takes for food or drugs to pass through the digestive tract, it may affect the absorption of other oral drugs.
If you suspect your pet or another animal was overdosed accidentally or has eaten this medication inadvertently, contact your veterinarian or the A.S.P.C.A.’s Animal Poison Control Center at 888.426.4435. Always bring the prescription container with you when you take your pet for treatment.
If you or someone else has accidentally ingested this medication call the National Capital Poison Center at 800.222.1222.
Different strengths or dosage forms of cisapride may have different storage requirements. Read the labeling or ask your pharmacist for the storage requirements of the prescription you receive.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
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This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.