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General Drug Information and Indications
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Aminopentamide hydrogen sulfate is a drug which is used to control vomiting, diarrhea, and gastrointestinal (GI) pain or spasms in dogs and cats. It works by decreasing motility and smooth muscle contractions in the GI tract. It may be given orally or your veterinarian may give it by injection. Aminopentamide hydrogen sulfate was marketed under the trade name of Centrine® and is FDA approved for use in dogs and cats. This drug is not available from a veterinary pharmaceutical manufacturer. Instead, it is compounded by a specialty pharmacy (What is compounding?).
Give this medication to your pet exactly as your veterinarian prescribes. If you miss giving your pet a dose of aminopentamide hydrogen sulfate, give the next dose as soon as you remember or, if it is close to the next scheduled dose, return to the regular schedule. Do not double dose to catch up.
Wash your hands after giving your pet this medication.
Be sure to discuss any side effects with your veterinarian immediately.
The most common side effects are dry mouth, dry eyes, and blurring of vision.
Less commonly your pet may develop delayed emptying of the stomach and GI tract. The medical term for this is illeus. Your pet may also develop hesitancy or difficulty urinating.
Keep this and all drugs out of reach of children. Aminopentamide hydrogen sulfate is a prescription drug and should be used according to your veterinarian’s directions. It should only be given to the animal for which it was prescribed. Do not give this medication to a person.
Aminopentamide hydrogen sulfate should not be used in animals with glaucoma. It should also be avoided in animals with stomach obstruction, intestinal obstruction, GI infections such as parvovirus, urinary obstruction, heart diseases, hyperthyroidism, high blood pressure or liver or kidney disease.
Aminopentamide hydrogen sulfate should not be used in elderly, pregnant, lactating or pediatric patients.
Be sure to review with your veterinarian any medications or supplements your pet may be receiving.
Antihistamines, procainamide, quinidine, meperidine, and certain tranquilizers may increase the effects of aminopentamide hydrogen sulfate.
Aminopentamide hydrogen sulfate may increase the effects of the following drugs: nitrofurantoin, phenylpropanolamine, and some diuretics.
Aminopentamide hydrogen sulfate may interfere with the action of metoclopramide.
If you suspect your pet or another animal was accidentally overdosed or has eaten this medication inadvertently, contact your veterinarian or the A.S.P.C.A.’s Animal Poison Control Center at 888.426.4435. Always bring the prescription container with you when you take your pet for treatment.
If you or someone else has accidentally ingested this medication call the National Capital Poison Center at 800.222.1222.
Different strengths or dosage forms of aminopentamide hydrogen sulfate may have different storage requirements. Read the labeling or ask your pharmacist for the storage requirements of the prescription you receive.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
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This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.