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Progesterone is a steroid hormone normally produced by the corpus luteum and by the placenta of pregnant mares. Exogenous progesterone is used to prevent mares from coming into heat, to synchronize estrus cycles of mares for better breeding efficiency, to organize, or regulate heat cycles during the mare's seasonal transition, and to help maintain pregnancy. It is also used to modify estrus-related behaviors that interfere with performance and pleasure riding in non-breeding mares.
When injectable progesterone is used in the non-pregnant mare to regulate the estrus cycle or synchronize estrus, it will suppress outward signs of estrus, although it will not consistently prevent ovulation. Consequently prostaglandin is commonly given at the end of a course of progesterone to cause lysis of the CL and predictable return to estrus. Injectable progesterone is commonly used for pregnancy maintenance and is accepted as safe in the pregnant and lactating mare. Pony breeds are similar to horses in their response to progesterone.
The most common side effect for progesterone in oil is injection site reaction. These reactions usually respond to hot compresses and NSAIDs.
• Progesterone should not be used in mares with chronic uterine infections.
• The long-term use of progesterone may delay the return to normal reproductive cycling in mares.
Rifampin may decrease progesterone's activity.
No specific information was found regarding overdose in the mare. Occasionally pregnant mares who have undergone surgery, or other major stress are given very high doses in an attempt to protect their pregnancy. Doses of 1-2 grams of injectable progesterone in oil have been given in clinical situations with no apparent detrimental effect.
Dr.
Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania.
She has a master's degree in animal science from the University of Delaware
and graduated from the University of Pennsylvania School of Veterinary Medicine
in 1982.
She began to develop her interest in client education and medical writing 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
You can purchase books by Dr. Forney at www.exclusivelyequine.com
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Wedgewood compounded veterinary preparations are not intended for use in food and food-producing animals.
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