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Pentosan polysulfate (PPS) is a heparin-like, semi-synthetic
polysaccharide ester derived from beechwood hemicellulose. PPS is a mild
anticoagulant, with anti-inflammatory, fibrinolytic and hypolipidemic
properties. In human medicine, PPS is used in the treatment of interstitial
cystitis, particularly in women. In veterinary medicine, PPS is used for
the management and treatment of OA. PPS is thought to help preserve cartilage
integrity and improve joint health by supporting anabolic activity of
chondrocytes and synoviocytes. It also provides protection from catabolic
events within the joint by reducing levels of cytokines and inflammatory
mediators within cartilage matrix and synovial fluid.
PPS is used systemically in horses as a part of conservative management/treatment of OA. Studies have shown therapeutic levels in synovial fluid following intra-muscular (IM) administration. PPS is usually administered by IM injection once a week for a series of four weeks. It may also be administered intra-articularly.
PPS is used in the medical management of OA and after
joint surgery in dogs. In both instances, PPS is injected either subcutaneously
or IM once a week for four consecutive weeks.
• PPS is generally well tolerated.
• Horses: Systemic PPS has been shown to elevate PTT for up to 24
hours. When used intra-articularly, there is the possibility of intra-
articular bleeding. Appropriate bandaging and rest post injection are
recommended.
• Dogs: Mild GI disturbances including vomiting, anorexia.
• PPS affects clotting time. It should be used
with caution in animals receiving anti-coagulants or those under going
surgery in the near future.
• Although no specific drug interactions were found, PPS should
be used with care in animals receiving other drugs that affect clotting
function.
• No specific information regarding overdose was found. PPS has weak anti-coagulant properties. Bleeding, thrombocytopenia, GI disturbance and liver function may be affected by overdose.
Dr.
Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania.
She has a master's degree in animal science from the University of Delaware
and graduated from the University of Pennsylvania School of Veterinary Medicine
in 1982.
She began to develop her interest in client education and medical writing 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
You can purchase books by Dr. Forney at www.exclusivelyequine.com
For More Information about Pentosan, please visit www.naturevet.com.au.
The information contained on this site
is general in nature and is intended for use as an informational aid. It does
not cover all possible uses, actions, precautions, side effects, or interactions
of the products shown, nor is the information intended as medical advice or
diagnosis for individual health problems or for making an evaluation as to the
risks and benefits of using a particular product. You should consult your doctor
about diagnosis and treatment of any health problems. Information and statements
have not been evaluated by the Food and Drug Administration ("FDA"),
nor has the FDA approved the products to diagnose, cure or prevent disease.
Wedgewood compounded veterinary preparations are not intended for use in food and food-producing animals.
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