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Acetyl-D-Glucosamine is an amino monosaccharide. It is
chemically related to glucosamine, chondroitin, and hyaluronic acid. These
naturally occurring amino monosaccharides are found in cartilage and
connective tissue. Glucosamine is commonly used to treat osteoarthritis in
both humans and animals and there is an ever-increasing body of scientific
evidence supporting its anti-inflammatory properties. Acetyl-D-Glucosamine
has been studied in vitro to a lesser extent but it appears to have promise
as a chondroprotective therapy.
The treatment and prevention of osteoarthritis is an important clinical area in both human and equine sports medicine. There has been extensive research focusing on cartilage protection and the anti-inflammatory properties found in some of the naturally occurring components of cartilage. Hyaluronic acid, and polysulfated gylcosaminoglycan (PSGAG) products have been approved for the equine market for many years. These products are thought to protect cartilage by inhibiting enzymes that breakdown cartilage, inhibiting prostaglandin, and decreasing inflammation. They may also stimulate the cells that rebuild cartilage and produce joint fluid.
Only one study has been done comparing Acetyl-D-Glucosamine to the FDA approved PSGAG product, Adequan. This study was funded by Luitpold, the manufacturer of Adequan and presented at the AAEP in 2004. In this study, Acetyl-D-Glucosamine was found to be not as effective as Adequan at the conventional dose and treatment interval. The author of the study goes on to state that while products such as Acetyl-D- Glucosamine are "likely" to have a "positive effect on injured or diseased equine joints" the work has not been done to determine an appropriate dose or treatment regime.
• Side effects from I.M. injection are rare. The most
common side effect is pain at the injection site. No side effects or adverse
reactions were seen in the 2004 study.
• No side effects or adverse reactions were seen in
the 2004 study.
• No published information regarding drug interactions has been found.
• No published information regarding overdose has been found.
Dr.
Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania.
She has a master's degree in animal science from the University of Delaware
and graduated from the University of Pennsylvania School of Veterinary Medicine
in 1982.
She began to develop her interest in client education and medical writing 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
You can purchase books by Dr. Forney at www.exclusivelyequine.com
The information contained on this site
is general in nature and is intended for use as an informational aid. It does
not cover all possible uses, actions, precautions, side effects, or interactions
of the products shown, nor is the information intended as medical advice or
diagnosis for individual health problems or for making an evaluation as to the
risks and benefits of using a particular product. You should consult your doctor
about diagnosis and treatment of any health problems. Information and statements
have not been evaluated by the Food and Drug Administration ("FDA"),
nor has the FDA approved the products to diagnose, cure or prevent disease.
Wedgewood compounded veterinary medicines are not intended for use in food and food-producing animals.
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