Links to studies on Cisplatin Beads
"Matrix III with 7% cisplatin demonstrated minimal adverse effect
on the normal tissue. The implantation procedure is simple and can be
performed in the standing patient. Precise dosing afforded by the implants
and assured release of cisplatin from the matrix for prolonged treatment
intervals would seem to be improvements compared to intralesional injection."
Excerpted from the study A biodegradable matrix for cisplatin to treat
equine skin neoplasia, authored by George P. Marble, K.E. Sullins, Marion
duPont Scott Equine Medical Center Department of Large Animal Clinical
Sciences.
"To minimize the systemic effects and increase exposure of the tumor
to the chemotherapeutic drug, intralesional injections and slow release
biodegradable polymer delivery systems have been developed. For injection
of cisplatin solution, the drug is mixed with sterile sesame oil and injected
in a cross-hatch pattern throughout the tumor site. Another form of local
therapy is the slow release biodegradable polymer delivery systems, which
are placed at the tumor site for local diffusion of chemotherapeutic medication.
Cisplatin-containing biodegradable beads have been successfully used to
treat cutaneous neoplasias in the horse."
Excerpted from the AAEP proceedings titled How to use bioabsorbable cisplatin
beads to treat cutaneous neoplasia, authored by Christina A. Hewes, DVM,
MS, Diplomate ACVS.
"Intralesional administration of cisplatin has been commonly used
for treatment of cutaneous tumors in horses and has been found to be effective
against a variety of solid tumors. When used in this manner, the drug
mixed with sterile sesame oil and injected in a crosshatch pattern throughout
the tumor site. Multiple injections are required with this technique (ie,
4 treatments administered a 2-week intervals). Difficulties have been
found with the intralesional injection technique, including difficulty
in performing injections in periocular sarcoids, leakage of the cisplatin
solution following injection, and unpredictability in the consistency
and stability of the emulsion. There is also a risk of accidental injection
for the veterinarian injecting the cisplatin, especially if there is inadequate
patient restraint or analgesia at the site of the injection.
For these reasons, various slow-release delivery systems that can be
implanted at the tumor site, resulting in local diffusion of the chemotherapeutic
agent, have been developed."
Excerpted from the JAVMA article Use of cisplatin-containing biodegradable
beads for treatment of cutaneous neoplasia in equidae: 59 cases (2000-2004),
authored by Christina A. Hewes, DVM and Kenneth E. Sullins, DVM, MS, DACVS.
About Cisplatin
Read the drug monograph
on Cisplatin
 Cisplatin
Beads (Matrix III™) are available exclusively from Wedgewood Pharmacy
and are compounded under license with Royer Animal Health. For more information
about Royer Animal Health, visit www.RoyerAH.com.
For more information on Cisplatin, visit Royer's
Cisplatin information page.
- Compounded using the Matrix III drug delivery technology
- 3mm in diameter
- 1.6mg/bead 3 beads/vial
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